You know, this was one of the hardest things for me to come to grips with when I first got married. You're not marrying your spouse only. You're marrying their whole family. In my case, my wife's family is pretty nice, so it wasn't too hard, but it was still an adjustment. That's why it was good for us to move away from our home town. It forces a healthy separation.
I think a lot of young couples get messed up because their in-laws get too nosey and won't leave them alone. It's almost like both man and wife need to talk to their parents before getting married to set healthy boundaries.
I also think some young people don't have enough wisdom to keep their marriage problems away from their in-laws. If you've got problems in your marriage, I think you need to seek counselling. If both the husband and wife truly want to save the marriage, counselling will usually work. Don't bring your parents into the mix -- that just makes everything messy, because your parents will probably take your side on everything (even if you're wrong), and then you'll feel justified in treating your spouse like a jerk, and it all goes down hill. An independent counsellor can help each person see how they're making things hard, and give both sides things to work on.
All that said, sometimes one person's heart isn't into keeping the marriage together, and there's really nothing the other person can do.... but that's just life. You fall off, and get back on again later. That's how our character is revealed -- how we deal with setbacks.