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I take the 64 all the way home to St. Louis!! Yes!!! It gets confusing as all get out. I typically get off before heading straight into the Lou. I take the back road and cross the Jefferson Bridge to Missouri closest to my MIL and sisters out in St. Peters. Most of my family live there and I use 55 south to take me to my mothers house- Home to Lambert's original home throwed rolls- yummy!  . If you drive through and don't plan to get off- stay on 64 and don't stop.!!!