I love to travel, but I don't pay attention to a specific website.
Last year, I flew to Germany from Las Vegas for only 424$ roundtrip in August 2007. I didn't buy the ticket from a general website but rather from the airline website itself. Sometimes the deals on the airline's website is better than offered through secondary websites.
In March 2007, I flew from SLC to Germany for 400$ roundtrip.
Usually, I fly to New Jersey where my family is at, from SLC for about 200$ roundtrip.
Last January 2007, my partner and I went to Mexico and it was like a package deal for about 700$ per person for one week. We enjoyed it very much.
So far for 2008, I haven't made any travel plans, but the main point here is that I don't focus on one website, but research around for the best prices.