Jillio-
1. In regard to your comment: "The only stem cell that is not specialized is at the embryonic stage." This is incorrect. "There are now 3 adult stem cell types that are pluripotent." Pluripotent is the same as undifferentiated or "non-specialized" as you put it. Since there are non-specialized adult stem cells, the path of regression is not required for treatment, only for research. Does that make sense? "Adult cells" do not need to be regressed because there are 3 of them that are non-specialized.
2. Most of these 20 - 30 articles showing the benefits of adult stem cells if not all ARE reputable, peer reviewed journal articles:
STEM CELLS AND HEARING LOSS - A BRIEF HISTORY
3. Most of these 2,090 articles ARE also from reputable, peer reviewed journal articles:
SCHOLARLY PAPERS CONTAINING ADULT "STEM CELLS" AND "HEARING LOSS" WITHOUT THE WORD "EMBRYONIC"
4. A random sampling of reputable, peer reviewed sources...
American Journal of Pathology
Gonda Department of Cell and Molecular Biology, House Ear Institute,
University of Texas Southwestern Medical Center - Center for Basic Neuroscience
University of Southern California Medical School - Department of Cell and Neurobiology
NeuroReport:Auditory and Vestibular Systems
Cell Transplantation
Otolaryngology & Head and Neck Surgery
University of Washington in Seattle
Virginia Merrill Bloedel Hearing Research Center
Medical University of South Carolina/Children’s Hospital Boston
"Departments of Otolaryngology and Neurosurgery, Graduate Program in Neuroscience, Stem Cell Institute, and Bioengineering, University of Minnesota"
ENT Depertment, Hippokrateion General Hospital of Athens, Greece
Otology & Neurotology
Cell Transplantation
5. I just found a few more articles on "Hair Cell Regeneration" but I apologize, I don't have time to go through them today:
Baird, R. A., Steyger, P. S., & Schuff, N. R. (1996) Mitotic and nonmitotic hair cell regeneration in the bullfrog vestibular otolith organs. Annals of the New York Academy of Sciences, 781, 59–70.
Bermingham, N. B., Hassan, B. A., Price, S. D., Vollrath, M. A., & Ben-Arie, N. et al. (1999). Math1: An essential gene for the generation of inner ear hair cells. Science, 284, 1837–1841.
Breuskin, I., Bodson, M., Thelen, N., Thiry, M., Nguyen, L., & Belachew, et al. (2008). Strategies to regenerate hair cells: Identification of progenitors and critical genes. Hearing Research, 236(1-2), 1–10.
Bryant, J., Goodyear, R., & Richardson, G. P. (2002). Sensory organ development in the inner ear: molecular and cellular mechanisms. British Medical Bulletin, 63, 39–57.
Coleman, B., de Silva, M. &Shepherd, R. K. (2007). Concise review: the potential of stem cells for auditory neuron generation and replacement. Stem Cells, 25(11), 2685–94.
Corwin, J. T. & Cotanche, D. A. (1988). Regeneration of sensory hair cells after acoustic trauma. Science, 240(4860), 1772–1774.
Izumikawa, J., Minoda, R., Kawamoto, K., Abrashkin, K. A., Swiderski, D. L., & Dolan, D. F. (2005). Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals. Natural Medicine, 11(3), 271–76.
Kawamoto, K., Ishimoto, S., Minoda, R., Brough, D. E., & Raphael, Y. (2003). Math1 gene transfer generates new cochlear hair cells in mature guinea pigs in vivo. Journal of Neuroscience, 23(11), 4395–4400.
Kelley, M. W. (2002). Determination and commiment of mechanosensory hair cells. The Scientific World Journal, 2, 1079–1094.
Li, H., & Heller, S. (2003). Pluripotent stem cells from the adult mouse inner ear. Natural Medicine, 9(10), 1293–9.
Ryals, B. M. & Rubel, E. W. (1988). Hair cell regeneration after acoustic trauma in adult cotumix quail. Science, 40, 1774-76.
Staecker, H., Praetorius, M., Kim, B., & Douglas, D. E. (2007). Vestibular hair cell regeneration and restoration of balance function induced by math1 gene transfer. Otology & Neurotology, 28(2), 223–31.
Stone, J., & Cotanche, D. (2007). Hair cell regeneration in the avian auditory epithelium. International Journal of Developmental Biology, 51, 633–647.
Zine, A., & de Ribaupierre, F. (2002). Notch/Notch ligands and Math1 expression patterns in the organ of Corti of wild-type and Hes1 and Hes5 mutant mice. Hearing Research, 170(1-2), 22–31.
6. These people who wrote the articles are scientists.
7. These people who make up the Science Advisory Board are also scientists.
RSCI Deputy Chairman, Shimon Slavin, MD
Professor of Medicine/Medical & Scientific Director
International Center for Cell Therapy & Cancer Immunotherapy(CTCI)
Dr. Zannos G. Grekos, MD, FAAC
Director of Cardiology & Vascular Disease, Regenocyte Therapeutic
Assistant Clinical Professor, Nova Southeastern University
Dr. Kitipan V. Arom
Associate Professor of Surgery
MD, PhD, FACS, FACC, FACCP, FR
If you need help finding anything specific, just give me a shout -
dsgrano@gmail.com
Please refrain from disrespectful comments like "duh!" I don't know you, yet I'll always treat you with respect. I'd ask the same of you. It also downgrades the level of communication from open exchange of ideas to one-up-man-ship and bashing. Thanks.